Journal of Dental Hygiene Science : eISSN 2233-7679

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Fig. 1.

The gene/genome-centric approach for the gut microbiome. Generally, 16S-rRNA based amplicon sequencing and whole shotgun sequencing are the two main metagenomic approaches for gut microbiome studies. From metagenome data, the taxonomic compositions and functional categories of the gut microbial communities, which may be associated with the health or disease state, can be inferred. Moreover, the combination of culturomics and next-generation sequencing (NGS) methods provides deeper information about the functional roles of specific gut microbial species. Other available “omics” data (transcriptomics, proteomics, metabolomics, and phenomics) provides much deeper insight into the functional role of gut microbes in human health and disease. Integrating these data with metagenomics data, especially metabolic models reconstructed from metagenomic studies, will provide a comprehensive view of metabolic interactions between microbes and host11). Adapted from the article of Ji and Nielsen (Front Genet 6: 219, 2015)12) in accordance with the Creative Commons Attribution (CC BY 4.0) license.

J Dent Hyg Sci 2019;19:86-95 https://doi.org/10.17135/jdhs.2019.19.2.86
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